Rodent Relics is 2.5D puzzle-platformer artefact inspired by games like Escape Goat, Toki Tori and Mutant Mudds.

The player controls a mouse in single-screen levels and is tasked with collecting every bit of cheese to complete the level. The mouse is unable to jump but can run on any wall and ceiling to activate switches and avoid traps.

Even though the camera does not move the player must manage a large play area at once: on specific tiles, the mouse can travel back and forth between the foreground and background areas.